Detailed view for PVX_000735

Basic information

TDR Targets ID: 268983
Plasmodium vivax, protein phosphatase PPM1, putative
Source Database / ID:  PlasmoDB 

pI: 5.5507 | Length (AA): 953 | MW (Da): 107332 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00481   Protein phosphatase 2C

Gene Ontology

Mouse over links to read term descriptions.
GO:0004722   protein serine/threonine phosphatase activity  
GO:0003824   catalytic activity  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
640 944 1a6q () 9 326 28.00 0 1 0.67 -0.55
13 192 4uos (A) 2 176 14.00 0.014 0.06 0.321077 -0.88
91 234 4mh6 (A) 6 146 13.00 0.25 0.03 0.278302 -0.56
122 227 2oto (A) 69 182 16.00 1 0 0.189428 -0.3
290 353 4qfh (A) 382 453 41.00 0.83 0.33 0.363356 -0.1
658 947 4rag (A) 29 330 22.00 0.000000066 1 0.572202 0.11
670 926 4rag (A) 39 305 33.00 0 1 0.659875 -0.47
682 910 4yzg (A) 86 345 36.00 0 1 0.543494 -0.3
686 863 2irm (A) 63 287 29.00 0.012 0.79 0.205979 0.93

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_149969)

Species Accession Gene Product
Arabidopsis thaliana AT1G48040   putative protein phosphatase 2C 13
Arabidopsis thaliana AT3G17250   putative protein phosphatase 2C 43
Arabidopsis thaliana AT3G62260   putative protein phosphatase 2C 49
Oryza sativa 4326717   Os01g0295700
Oryza sativa 4337723   Os05g0134200
Plasmodium falciparum PF3D7_0410300   protein phosphatase PPM1, putative
Plasmodium knowlesi PKNH_0308400   protein phosphatase PPM1, putative
Plasmodium vivax PVX_000735   protein phosphatase PPM1, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_000735 (Plasmodium vivax), protein phosphatase PPM1, putative
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